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MyBioSource/Duck A Disintegrin and Metalloprotease 10 ELISA Kit/MBS051768/10x96-Strip-Wells

MyBioSource/Duck A Disintegrin and Metalloprotease 10 ELISA Kit/MBS051768/10x96-Strip-Wells
  • MyBioSource/Duck A Disintegrin and Metalloprotease 10 ELISA Kit/MBS051768/10x96-Strip-Wells
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Founded originally in Vancouver, British Columbia in 2006 by three enthusiastic scientists passionate about providing the best biological reagents worldwide, MyBiosource, Inc. was incorporated as a company with big visions. Since 2007, we have relocated our headquarters to sunny Southern California, San Diego (USA).

"Our primary mission at MyBiosource, Inc. is to provide #1 quality reagents worldwide."

As a goal towards achieving our primary mission, we aim to provide our customer base of researchers and scientists with a one-stop searchable collection of biological reagents, such as monoclonal or polyclonal antibodies, recombinant proteins or ELISA kits.

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 ProductName  ADisintegrinandMetalloprotease10(ADAM10),ELISAKit
 AlsoKnownAs  DuckADisintegrinandMetalloprotease10ELISAKit
 ProductGeneName  ADAM10elisakit[SimilarProducts]
 ResearchUseOnly  ForResearchUseOnly.Notforuseindiagnosticprocedures.
 RequestforManualInsert  Request Manual
 ChromosomeLocation  Chromosome:15;NC_000015.9(58888510..59042177,complement).Location:15q22
 OMIM  602192
 3DStructure  ModBase3DStructureforO14672
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 SpeciesReactivity  Duck
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 PreparationandStorage  Storeallreagentsat2-8degreeC
 ProductNote  OurELISAassaysaredynamicresearchtoolsandsometimestheymaybeupdatedandimproved.Iftheformatofthisassayisimportanttoyouthenpleasecontactourtechnicalsupportteamwithapresalesinquirybeforeplacinganorder.Wewillconfirmthecurrentdetailsoftheassay.
 OtherNotes  SmallvolumesofADAM10elisakitvial(s)mayoccasionallybecomeentrappedinthesealoftheproductvialduringshipmentandstorage.Ifnecessary,brieflycentrifugethevialonatabletopcentrifugetodislodgeanyliquidinthecontainer`scap.Certainproductsmayrequiretoshipwithdryiceandadditionaldryicefeemayapply.
 SearchableTermsforADAM10purchase  MBS051768isaready-to-usemicrowell,stripplateELISA(enzyme-linkedimmunosorbentassay)KitforanalyzingthepresenceoftheADisintegrinandMetalloprotease10(ADAM10)ELISAKittargetanalytesinBIOLOGicalsamples.TheconcentrationgrADIentsofthekitstandardsorpositivecontrolsrenderatheoreticalkitdetectionrangeinbiologicalresearchsamplescontainingADAM10.TheELISAanalyticalbiochemicaltechniqueoftheMBS051768kitisbasedonADAM10antibody-ADAM10antigeninteractions(immunosorbency)andanHRPcolorimetricdetectionsystemtodetectADAM10antigentargetsinsamples.TheELISAKitisdesignedtodetectnative,notrecombinant,ADAM10.Appropriatesampletypesmayincludeundilutedbodyfluidsand/ortissuehomogenates,secretions.Qualitycontrolassaysassessingreproducibilityidentifiedtheintra-assayCV(%)andinter-assayCV(%).
NCBI/UniprotdatabelowdescribegeneralgeneinformationforADAM10.Itmaynotnecessarilybeapplicabletothisproduct.
 NCBIGI#  2393947
 NCBIGeneID  102
 NCBIAccession#  AAC51766.1[OtherProducts]
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 UniProtPrimaryAccession#  O14672[OtherProducts]
 UniProtSecondaryAccession#  Q10742;Q92650[OtherProducts]
 UniProtRelatedAccession#  O14672[OtherProducts]
 MolecularWeight  84,142Da
 NCBIOfficialFullName  ADAM10
 NCBIOfficialSynonymFullNames  ADAMmetallopeptidasedomain10
 NCBIOfficialSymbol  ADAM10[SimilarProducts]
 NCBIOfficialSynonymSymbols  
kuz;AD10;MADM;CD156c;HsT18717
[SimilarProducts]
 NCBIProteinInformation  disintegrinandmetalloproteinasedomain-containingprotein10;CDw156;ADAM10;kuzbanianproteinhomolog;mammaliandisintegrin-metalloprotease;adisintegrinandmetalloproteasedomain10;adisintegrinandmetalloproteinasedomain10
 UniProtProteinName  Disintegrinandmetalloproteinasedomain-containingprotein10
 UniProtSynonymProteinNames  
CDw156;Kuzbanianproteinhomolog;Mammaliandisintegrin-metalloprotease
 ProteinFamily  Disintegrinandmetalloproteinasedomain-containingprotein
 UniProtGeneName  ADAM10[SimilarProducts]
 UniProtSynonymGeneNames  KUZ;MADM;ADAM10[SimilarProducts]
 UniProtEntryName  ADA10_HUMAN
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 NCBISummaryforADAM10  MembersoftheADAMfamilyarecellsurfaceproteinswithauniquestructurepossessingbothpotentialadhesionandproteasedomains.ThisgeneencodesandADAMfamilymemberthatcleavesmanyproteinsincludingTNF-alphaandE-cadherin.[providedbyRefSeq,Jul2008]
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 UniProtCommentsforADAM10  ADAM10:Cleavesthemembrane-boundprecursorofTNF-alphaat'76-Ala-|-Val-77'toitsmaturesolubleform.ResponsIBLefortheproteolyticalreleaseofsolubleJAM3fromendothelialcellssurface.Responsiblefortheproteolyticreleaseofseveralothercell-surfaceproteins,includingheparin-bindingepidermalgrowth-likefactor,ephrin-A2andforconstitutiveandregulatedalpha-secretasecleavageofamyloidprecursorprotein(APP).Contributestothenormalcleavageofthecellularprionprotein.InvolvedinthecleavageoftheadhesionmoleculeL1atthecellsurfaceandinreleasedmembranevesicles,suggestingavesicle-basedproteaseactivity.ControlsalsotheproteolyticprocessingofNotchandmediateslateralinhibitionduringneurogenesis.ResponsiblefortheFasLectodomainsheddingandforthegenerationoftheremnantADAM10-processedFasL(FasLAPL)transmembraneform.AlsocleavestheectodomainoftheintegralmembraneproteinsCORINandITM2B.MayregulatetheEFNA5-EPHA3signaling.

Proteintype:Celladhesion;Cellsurface;Protease;Motility/polarity/chemotaxis;EC3.4.24.81;Membraneprotein,integral;Vesicle

ChromosomalLocationofHumanOrtholog:15q22

CellularComponent:Golgiapparatus;cellsurface;focaladhesion;membrane;intracellularmembrane-boundorganelle;postsynapticdensity;cytoplasm;plasmamembrane;integraltomembrane;Golgi-associatedvesicle;nucleus

MolecularFunction:integrinbinding;proteinbinding;proteinhomodimerizationactivity;zincionbinding;metallopeptidaseactivity;metalloendopeptidaseactivity;endopeptidaseactivity;proteinkinasebinding;SH3domainbinding;receptorbinding

BiologicalProcess:integrin-mediatedsignalingpathway;epidermalgrowthfactorreceptorsignalingpathway;axonguidance;extracellularmatrixorganizationandbiogenesis;Notchsignalingpathway;inuteroembryonicdevelopment;constitutiveproteinectodomainproteolysis;membraneproteinectodomainproteolysis;Notchreceptorprocessing;negativeregulationofcelladhesion;positiveregulationofcellgrowth;proteinaminoacidphosphorylation;extracellularmatrixdisassembly;collagencatabolicprocess;PMA-induciblemembraneproteinectodomainproteolysis;monocyteactivation;cell-cellsignaling;positiveregulationofcellproliferation;ephrinreceptorsignalingpathway;positiveregulationofcellmigration

Disease:ReticulateAcropigmentationOfKitamura;AlzheimerDisease18
 ResearchArticlesonADAM10  1.MiR-144andMir-451negativelyregulatortheADAM10proteinexpressionandmaycontributetoAlzheimerdiseasepathogenesis.
 Precautions  AllofMyBioSource"sProductsareforscientificlaboratoryresearchpurposesandarenotfordiagnostic,therapeutics,prophylacticorinvivouse.Throughyourpurchase,youexpresslyrepresentandwarranttoMyBioSourcethatyouwillproperlytestanduseanyProductspurchasedfromMyBioSourceinaccordancewithindustrystandards.MyBioSourceanditsauthorizeddistributorsreservetherighttorefusetoprocessanyorderwherewereasonablybelievethattheintendedusewillfalloutsideofouracceptableguidelines.
 Disclaimer  Whileeveryeffortsweremadetoensuretheaccuracyoftheinformationprovidedinthisdatasheet,MyBioSourcewillnotbeliableforanyomissionsorerrorscontainedherein.MyBioSourcereservestherighttomakechangestothisdatasheetatanytimewithoutpriornotice.

ItistheresponsibilityofthecustomertoreportproductperformanceissuestoMyBioSourcewithin30daysofreceiptoftheproduct.PleasevisitourTerms&Conditionspageformoreinformation.